Deletion of RD1 fromMycobacterium tuberculosisMimics Bacille Calmette‐Guérin Attenuation
نویسندگان
چکیده
منابع مشابه
Deletion of RD1 from Mycobacterium tuberculosis mimics bacille Calmette-Guérin attenuation.
The tuberculosis (TB) vaccine bacille Calmette-Guérin (BCG) is a live attenuated organism, but the mutation responsible for its attenuation has never been defined. Recent genetic studies identified a single DNA region of difference, RD1, which is absent in all BCG strains and present in all Mycobacterium tuberculosis (MTB) strains. The 9 open-reading frames predicted within this 9.5-kb region a...
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a National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, 2300 Dayton Avenue, Ames, IA 50010, USA b University of Texas Medical Branch, Department of Pediatrics and the Sealy Center for Vaccine Development, Galveston, TX 77555, USA c Howard Hughes Medical Institute and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY ...
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BACKGROUND Tuberculosis is an essential problem for healthcare systems especially in developing countries. All newborns are given Bacillus Calmette-Guérin (BCG) vaccine in Iran which is prepared from live bovine tuberculosis bacillus, and is given to protect against tuberculosis. Osteomyelitis secondary to BCG vaccination is rare and usually involves epiphysis of long tubular bones. METHODS 4...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2003
ISSN: 0022-1899,1537-6613
DOI: 10.1086/345862